Responsible Official Resource Manual

Changes and Highlights

This is a living document subject to ongoing improvement. Feedback or suggestions for improvement from entities registered with the Federal Select Agent Program (FSAP), as well as the general public, are welcomed.

Submit comments directly to FSAP at:


Revision History:

  • June 2016: Initial posting.
  • March 2017: Revised due to updates to the select agent regulations.
  • February 2019: Revised to remove “Three Year Cycle of RO Tasks” section and reference FSAP’s recently issued policy and guidance on entity annual internal inspections.
  • December 2020: Revised to include updated hyperlinks.

Knowledge Check

Page last reviewed: January 29, 2021, 04:50 PM