Select Agents and Toxins Exclusions: Excluded Toxins Modified to be Less Potent or Toxic, Section 73.3 (e)
Anhydrotetrodotoxin, a derivative of wild-type tetrodotoxin (effective May 15, 2015)
Experimental evidence suggests that anhydrotetrodotoxin does not possess sufficient acute toxicity to pose a significant public health threat. Anhydrotetrodotoxin has been shown to have a significantly higher LD50 value than tetrodotoxin in a mouse model [Anhydrotetrodotoxin – LD50 (Oral, mouse) = 16.9 mg/kg compared to tetrodotoxin – LD50 (Oral, mouse) = 0.334 mg/kg]Reference(s):
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