Select Agents and Toxins

The Public Health Security and Bioterrorism Preparedness and Response Act of 2002, Subtitle A of Public Law 107–188 requires the Department of Health and Human Services (HHS) to establish and regulate a list of biological agents and toxins that have the potential to pose a severe threat to public health and safety. The Agricultural Bioterrorism Protection Act of 2002 requires the United States Department of Agriculture (USDA) to establish and regulate a list of biological agents that have the potential to pose a severe threat to animal health and safety, plant health and safety, or to the safety of animal or plant products (Select Agents). CDC and APHIS share responsibility for some agents because they potentially threaten both humans and animals (overlap agents). The laws require HHS and USDA to review and republish the lists of Select Agents and toxins on at least a biennial basis.

This page includes links to the list of Select Agents and toxins and information about additions or deletions that have been made to the list based on recommendations made from the biennial review or advances in research.

Select Agents and Toxins List
Select Agents and Toxins Exclusions
Select Agents and Toxins Restricted Experiments
Permissible Toxin Amounts