National Select Agent Registry phone numbers for APHIS (301-851-3300) and CDC (404-718-2000).
Last Updated: Wednesday, April 02, 2014

Select Agents and Toxins List

The following biological agents and toxins have been determined to have the potential to pose a severe threat to both human and animal health, to plant health, or to animal and plant products. An attenuated strain of a select agent or an inactive form of a select toxin may be excluded from the requirements of the Select Agent Regulations. The list of excluded agents and toxins can be found at:




7 CFR Part 331, 9 CFR Part 121, and 42 CFR Part 73








HHS SELECT AGENTS AND TOXINS                                                            OVerlap select agents and toxins 

Abrin                                                                                                                   Bacillus anthracis *

Botulinum neurotoxins*                                                                                  Bacillus anthracis Pasteur strain

Botulinum neurotoxin producing species of Clostridium*                       Brucella abortus

Conotoxins (Short, paralytic alpha conotoxins                                           Brucella melitensis             

   containing the following amino acid                                                         Brucella suis

   sequence X1CCX2PACGX3X4X5X6CX7)1                                                   Burkholderia mallei*

Coxiella burnetii                                                                                              Burkholderia pseudomallei*           

Crimean-Congo haemorrhagic fever virus                                                 Hendra virus

Diacetoxyscirpenol                                                                                          Nipah virus

Eastern Equine Encephalitis virus3                                                             Rift Valley fever virus

Ebola virus*                                                                                                       Venezuelan equine encephalitis virus3

Francisella tularensis*                                                                                       

Lassa fever virus                                                                                                

Lujo virus                                                                                                           USDA SELECT AGENTS AND TOXINS

Marburg virus*                                                                                                   African horse sickness virus

Monkeypox virus3                                                                                              African swine fever virus 

Reconstructed replication competent forms of the 1918                         Avian influenza virus3

  pandemic influenza virus containing any portion of the                          Classical swine fever virus

  coding regions of all eight gene segments (Reconstructed                 Foot-and-mouth disease virus*

  1918 Influenza virus)                                                                                     Goat pox virus

Ricin                                                                                                                    Lumpy skin disease virus

Rickettsia prowazekii                                                                                      Mycoplasma capricolum3

SARS-associated coronavirus (SARS-CoV)                                               Mycoplasma mycoides3    

Saxitoxin                                                                                                             Newcastle disease virus2,3

South American Haemorrhagic Fever viruses:                                           Peste des petits ruminants virus

      Chapare                                                                                                       Rinderpest virus*   

     Guanarito                                                                                                      Sheep pox virus

     Junin                                                                                                              Swine vesicular disease virus



Staphylococcal enterotoxins A,B,C,D,E subtypes                                      USDA Plant ProtEction and Quarantine (PPQ)

T-2 toxin                                                                                                              select agents and toxins      

Tetrodotoxin                                                                                                       Peronosclerospora philippinensis (Peronosclerospora

Tick-borne encephalitis complex (flavi) viruses:                                        sacchari)

     Far Eastern subtype                                                                                   Phoma glycinicola (formerly Pyrenochaeta glycines)   

     Siberian subtype                                                                                         Ralstonia solanacearum

Kyasanur Forest disease virus                                                                     Rathayibacter toxicus

Omsk hemorrhagic fever virus                                                                      Sclerophthora rayssiae

Variola major virus (Smallpox virus)*                                                           Synchytrium endobioticum

Variola minor virus (Alastrim)*                                                                       Xanthomonas oryzae

Yersinia pestis*                                                                                                   




*Denotes Tier 1 Agent

1 C = Cysteine residues are all present as disulfides, with the 1st and 3rd Cysteine, and the 2nd and 4th Cysteine forming specific disulfide bridges; The consensus sequence includes known toxins α-MI and α-GI (shown above) as well as α-GIA, Ac1.1a, α-CnIA, α-CnIB; X1 = any amino acid(s) or Des-X; X2 = Asparagine or Histidine; P = Proline;  A = Alanine;  G = Glycine; X3 = Arginine or Lysine;  X4 = Asparagine, Histidine, Lysine, Arginine, Tyrosine, Phenylalanine or Tryptophan; X5 = Tyrosine, Phenylalanine, or Tryptophan;  X6 = Serine, Threonine, Glutamate, Aspartate, Glutamine, or Asparagine;  X7 = Any amino acid(s) or Des X and; “Des X” = “an amino acid does not have to be present at this position.”  For example if a peptide sequence were XCCHPA then the related peptide CCHPA would be designated as Des-X.
2 A virulent Newcastle disease virus (avian paramyxovirus serotype 2) has an intracerebral pathogenicity index in day-old chicks (Gallus gallus) of 0.7 or greater or has an amino acid sequence at the fusion (F) protein cleavage site that is consistent with virulent strains of Newcastle disease virus.  A failure to detect a cleavage site that is consistent with virulent strains does not confirm the absence of a virulent virus.
3 Select agents that meet any of the following criteria are excluded from the requirements of this part: Any low pathogenic strains of avian influenza virus, South American genotype of eastern equine encephalitis virus , west African clade of Monkeypox viruses, any strain of Newcastle disease virus which does not meet the criteria for virulent Newcastle disease virus, all subspecies Mycoplasma capricolum except subspecies capripneumoniae (contagious caprine pleuropneumonia), all subspecies Mycoplasma mycoides except subspecies mycoides small colony (Mmm SC) (contagious bovine pleuropneumonia), and any subtypes of Venezuelan equine encephalitis virus except for Subtypes IAB or IC, provided that the individual or entity can verify that the agent is within the exclusion category. 9/10/13

Select Agents and Toxins List

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